Archived U.S. Federal Guidelines - Clinical Guidelines Program

November 2025

Included below are version-specific, unedited documents containing scientific and clinical evidence generated by the U.S. federal government on the date indicated for each file. The Clinical Guidelines Program is hosting these time-stamped versions to ensure users have ongoing access to the robust evidence base underlying our guidelines, regardless of redactions, editing, alterations, or deletions by the current federal administration. The Clinical Guidelines Program follows the guiding principle that clinicians should be provided with data-driven science in support of HIV, sexually transmitted infections, hepatitis C virus, and substance use prevention, treatment, and care for all.